Chemical properties of sodium channel inhibitors which determine affinity to resting and inactivated states
نویسندگان
چکیده
منابع مشابه
A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel.
Voltage-gated sodium channels are inhibited by local anesthetic drugs. This inhibition has complex voltage- and frequency-dependent properties, consistent with a model in which the sodium channel has low affinity for local anesthetics when it is in resting states and higher affinity when it is in open or inactivated states. Two residues, a phenylalanine (F1710) and a tyrosine (Y1717), in transm...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2011
ISSN: 1662-453X
DOI: 10.3389/conf.fnins.2011.84.00169